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Publication Synthesis and evaluation of diazine containing bioisosteres of ferruginine as ligands fo

Bioorg Med Chem. Oct;9(10) Synthesis and evaluation of diazine containing bioisosteres of (-)- ferruginine as ligands for nicotinic acetylcholine. A series of hitherto unknown enantiopure (А)- ferruginine analogues of type 8 and 9 was 5S)-enantiomer] turned out to be the most active nAChR ligand with a 12 -fold higher affinity toward type 7 published recently from our laboratory (Gьndisch Synthesis and evaluation of diazine containing bioisosteres of (А)- ferru-. Official Full-Text Publication: Synthesis and evaluation of diazine containing bioisosteres of (−)- ferruginine as ligands for nicotinic acetylcholine. Publications by Daniela Gundisch, University of Bonn (Chemistry Tree) N-[11C] methyl(1,3-benzodioxolyl)butanamine (MBDB): Synthesis, quality . and evaluation of diazine containing bioisosteres of (-)- ferruginine as ligands for. pre- synthesized receptors (high affinity receptor) from a sub-membranous pool. NAChRs (+)- Ferruginine Fe 1 is a potent neurotoxin containing an 8- azabicyclo[]octene develop new potent nAChR ligands bearing diazine moieties , N. CH Data concerning biological evaluation has not been published. Synthesis and Evaluation of Diazine Containing Bioisosteres of ()- Ferruginine as Ligands for Nicotinic The structures of the novel diazine analogues 6–8 of ()- ferruginine (3) were assigned on the . The affinity determined was in good agreement with pre- viously published values26 (Kd= nM).

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